No, not possible at the moment - the only way an app can embed a content-blocked web browser is with the new SFSafariViewController, and that specifically *doesn't* allow for apps to customize the page content. We are planning to migrate from UIWebView to WKWebView (which is a lot faster) as soon as we drop iOS 8 support - needed to wait for 9 to move to that because the iOS 8 iteration didn't allow for loading offline data (e.g. in EPUBs) - but I don't know of any way to access content blocking in a non-system-supplied web view.
However, if a website loads awkwardly you can always tap on the glasses icon to pull it up in reading mode + skip most of the cruft. Also, assuming no major setbacks we should have split screen mode working on the latest iPads at least and that should make it very efficient to pull up words in Pleco while browsing the web with regular Safari.